Increasing Efficiency in Chromatography

Achieving Greater Consistency in Purification by Implementing Ultrasonic Flow Meters and Air Bubble Detectors

Chromatography is essential in bioprocessing for identifying, separating, and purifying biomolecules like proteins and monoclonal antibodies. To optimize efficiency, process engineers rely on non-contact clamp-on flow meters and air bubble detectors, which enhance accuracy, repeatability, and automation without disrupting the flow path.

Get more details about our featured products:

SONOFLOW CO.55 Flow Meters

SONOCHECK ABD06 Bubble Detectors

Achieving Greater Consistency in Chromatography

Chromatography requires tight control of flow rates to ensure reproducibility, efficiency, and to maintain high product quality. Variations in flow rates can lead to inconsistent separation, lower yield, and reduced product quality. Ultrasonic clamp-on flow meters measure liquid flow rates externally, preserving sterility and preventing contamination in HPLC (High-Performance Liquid Chromatography) and other chromatography systems.

Air bubbles are a major challenge in chromatography because they can damage the columns, disrupt flow uniformity, and lead to inconsistent separations. Even smallest air bubbles can affect pressure profiles and compromise the integrity of the purification process. Non-contact ultrasonic bubble detectors provide a cost-effective and robust solution for real-time monitoring of air in liquid streams.

SONOFLOW CO.55 SD V3.0
Non-contact SONOFLOW CO.55 SD V3.0 Flow Meter with Touch Display for GMP environments

Real-Time Flow Measurement and Air Bubble Detection

Non-invasive clamp-on flow meters and bubble detectors are crucial for chromatography. These technologies improve process efficiency, increase yield, and ensure precise control of critical parameters.

By using these advanced tools, manufacturers can optimize their chromatography processes, reduce downtime, and achieve greater consistency in the purification of biopharmaceuticals, increasing overall bioprocess efficiency.

Your Benefits

  • High accuracy and precise flow control
  • Early detection of air bubbles to prevent column damage and ensure optimal chromatographic performance
  • Reproducible results and higher product yield
  • Integration of process control systems to enable automatic adjustments to avoid problems associated with air bubbles, reducing the need for manual monitoring

Benefit from our flow meters and air bubble detectors!

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Stefanie Schmidt

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